One molecule thought to determine secretion specificity is a T3 SS-associated chaperone however, no T3 SS 2-specific chaperone has been identified.
However, it is not known how specific effectors are secreted through a specific T3 SS when both T3SSs are expressed within bacteria. Effector proteins secreted by these T3SSs are delivered into host cells, leading to cell death or diarrhea. The enteropathogen Vibrio parahaemolyticus possesses two sets of type III secretion systems, T3 SS1 and T3 SS 2. Identification of the Vibrio parahaemolyticus type III secretion system 2-associated chaperone VocC for the T3 SS 2-specific effector VopC.Īkeda, Yukihiro Kodama, Toshio Saito, Kazunobu Iida, Tetsuya Oishi, Kazunori Honda, Takeshi
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